1 in 8 stricken by Covid develops symptom – study




The Manila Times



ONE in eight people who get coronavirus develop at least one symptom of long Covid, one of the most comprehensive studies on the condition to date suggested on Thursday. With more than half a billion coronavirus cases recorded worldwide since the start of the pandemic, there has been rising concern about the lasting symptoms seen in people with long Covid. Almost none of the existing research, however, has compared long Covid sufferers with people who have never been infected, making it possible that some of the health problems were not caused by the virus. A new study published in The Lancet journal asked more than 76,400 adults in the Netherlands to fill out an online questionnaire on 23 common long Covid symptoms. Between March 2020 and August 2021, each participant filled out the questionnaire 24 times. During that period, more than 4,200 of them — 5.5 percent — reported catching Covid. Of those with Covid, over 21 percent had at least one new or severely increased symptom three to five months after becoming infected. Nearly 9 percent of a control group which did not have Covid, however, reported a similar increase. This suggested that 12.7 percent of those who had Covid — around 1 in 8 — suffered from long-term symptoms, the study said. The research also recorded symptoms before and after Covid infection, allowing the researchers to further pinpoint exactly what was related to the virus. It found that common long Covid symptoms include chest pain, breathing difficulties, muscle pain, loss of taste and smell, and general fatigue. ‘Major advance’ One of the study’s authors, Aranka Ballering of the Dutch University of Groningen, said long Covid was “an urgent problem with a mounting human toll.” “By looking at symptoms in an uninfected control group and in individuals both before and after SARS-CoV-2 infection, we were able to account for symptoms which may have been a result of non-infectious disease health aspects of the pandemic, such as stress caused by restrictions and uncertainty,” she added. The authors of the study said its limitations included that it did not cover later variants, such as Delta or Omicron, and did not collect information about some symptoms such as brain fog, which has since been considered a common sign of long Covid. Another study author, Judith Rosmalen, said “future research should include mental health symptoms” such as depression and anxiety, as well as aspects like brain fog, insomnia and a feeling of malaise after even minor exertion. Christopher Brightling and Rachael Evans, experts from Britain’s Leicester University who were not involved in the study, said it was “a major advance” on previous long Covid research because it had an uninfected control group. “Encouragingly, emerging data from other studies” suggests there is a lower rate of long Covid in people who have been vaccinated or infected with the Omicron variant, they said in a linked Lancet comment. Against emerging variants, a fourth dose of AstraZeneca vaccine remains effective. Vaccine manufacturer AstraZeneca believes that it does not need to reformulate its vaccines as its Vaxzevria vaccine continues to provide ample protection against emerging coronavirus disease 2019 (Covid-19) variants such as the “Centaurus” variant. Speaking at a media event on Friday in Manila, Dr. Bruce Mungall, AstraZeneca Asia area medical director for vaccines and immune therapies, said the fourth dose or second booster of the vaccine increased protection against symptomatic disease by as much as 73 percent, compared with just 26 percent when that individual had the third dose or first booster shot of Vaxzevria based on a study from Thailand. The country and Vietnam are the only ones in Southeast Asia that use the AstraZeneca vaccine as a fourth booster dose. Mungall said nearly the same percentage was also reached when one used the messenger ribonucleic (mRNA) vaccine as the second booster or fourth dose. “The broader message is any vaccine you have available for booster dosing will give you protection, but in the Omicron perspective, three doses may not be enough, you may need the fourth dose to limit the spread of the virus,” he added. Mungall said they will also conduct a separate clinical trial in the Philippines regarding the safety and effectiveness of the second booster dose of Vaxzevria vaccine, and its interim analysis is expected to be released by the second semester of this year. He also said the creation and the development of a variant-specific vaccine is a “time-consuming process,” and believes that the current formulation of the vaccine will continue to be effective even with emerging subvariants, such as the BA.2.75 or Centaurus variant. “Based on the data that we have seen, we have seen relative consistent effectiveness against hospitalization and death . . . I am relatively confident that which variant comes next, the current vaccines will provide protection against those serious outcomes,” Mungall added.